Synthesis and mechanism study of transition metal promoted radical reactions of trichloromethyl group containing compounds.
Green approach for the synthesis of biologically important organic molecules by “Click-Chemistry”.
Development of new methodologies for the synthesis of biologically significant organic molecules. Interdisciplinary approach for the synthesis of high energy molecules.
Note: Ph. D. positions are available for a highly motivated UGC-CSIR NET, JRF or GATE qualified candidates.
Experience :
14 years
Others:Recent Publications –
Ragshaniya, A.; Kumar, V.;Tittal, R. K.; Lal, K.; Nascent pharmacological advancement in adamantane derivatives Arch. Pharm. 2024, https://doi.org/10.1002/ardp. 202300595 (SCI; I.F.: 5.1)
Kumar, S.; Singh, G.;Tittal, R. K.*;Singh, J.; Ghule, V. D.; Sharma, R.; Selective quinizarin-linked bis-1,2,3-triazoles as probes for Fe(II)/(III): Characterization, metal ion binding, DFT, and antiallergy activity via docking studies J. Mol. Struct 2024, 1299, 137142. (SCI; I.F.: 3.841)
Lal, B.; Kumar, S.;Tittal, R. K.*; Singh, G.; Singh, J.; Ghule, V. D.; Mathpathi, R. S.; Sabane, J. K.; 4-aminoantipyrine linked bis-1,2,3-triazole based probes for Cu(II) sensing J. Mol. Struct 2024, 1297, 136995. (SCI; I.F.: 3.841)
Kumar, S.; Lal, B.;Tittal, R. K.*; Green Synthesis of 1,2,3-Triazoles: A Sustainable Approach Green Chemistry 2023, DOI: 10.1039/D3GC04346K (SCI; I.F.: 9.8)
Grover, A.; Kumar, A.;Tittal, R. K.; Lal, K.; Dehydroacetic acid a privileged medicinal scaffold: A concise review Arch. Pharm. 2023, e2300512 (SCI; I.F.: 5.1)
Lal, B.; Tittal, R. K.*; Mathpathi, R. S.; Ghule, V. D.; Nehra, N.; Lal, K. Synthesis, X-ray crystallography, antimicrobial, molecular docking, and DFT study of bis-triazoles linked ampyrone J. Mol. Struct 2023, 1294, 136455. (SCI; I.F.: 3.841)
Singh, G.; Lal, B.; Singh, R.; George, N.; Singh, G.; Kaur, G.; Singh, H.; Tittal, R. K.; Kaur, G; Singh, J., Ampyrone appended 1,2,3-triazole as selective fluorescent Cu(II)ion sensor: DFT and Docking findings Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2023, 302, 123163. https://doi.org/10.1016/j.saa.2023.123163. (SCI; I.F.: 4.4)
Kumar, S.; Lal, B.; Tittal, R. K.*, Singh, G.; Singh, J.; Ghule, V. D.; Sharma, R. Sabane, J.K. A Selective Chemosensor via Click Chemistry for Cu2+ and Hg2+ Ions in Organic Media Sensors & Diagnostics 2023, DOI: 10.1039/D3SD00109A (SCI; I.F.: Not updated)
Kumar, S.; Gadiyaram, S.; Tittal, R. K.*, Ghule, V. D.; Sharma, R. Fluorescent molecular probe to detect and differentiate Fe3+ from other metal ions J. Mol. Struct 2023,1290, 135940. (SCI; I.F.: 3.841)
Sharma, K.; Tittal, R.K.*; Lal, K.; Mathpathi, R. S.; Ghule, V.D., Fluorescent 7-Azaindole N-linked 1,2,3-triazole: Synthesis and Study of Antimicrobial, Molecular Docking, ADME and DFT Properties, New J. Chem. 2023 , 47, 9077. (SCI; I.F.: 3.925)
Kumar, V.; Lal, K.; Naveen; Tittal, R.K.* The fate of heterogeneous catalysis & click chemistry for 1,2,3-triazoles: Nobel prize in chemistry 2022, Catalysis Communication 2023, 176, 106629. (SCI; I.F.: 3.51)
Yadav, M.; Lal, K.; Jose, D.A.; Ghule, V.D.; Tittal, R.K.* Synthesis, Photophysical and DFT Investigations on 1,2,3-Triazoles linked to Chalcone and Chalco-pyrene Chemical Papers 2023, 10.1007/s11696-023-02794-4 (SCI; I.F.: 2.146)
Sandhu, N.; Singh, A.P.; Pandey, S.K.; Ghule, V.D.; Tittal, R.K.; Yadav, R.K.; Shrivastava, R. Synthesis, characterization of dialkylated erythrosin B derivatives and their utility as a propitious anti-microbial agent Main Group Chemistry 2023, 22, 105-113. (Scopus; I.F.: 1.068)
Kumar, V.; Lal, K.; Kumar, A.; Tittal, R.K. Singh, M.B..; Singh, P. Efcient synthesis, antimicrobial and molecular modelling studies of 3‑sulfenylated oxindole linked 1,2,3‑triazole hybrids Res. Chem. Intermed. 2023, 49, 917-937. (SCI; I.F.: 3.134)
Kumar, A.; Lal, K.; Kumar, L.; Kumar, A.; Naveen, Tittal, R.K. Phenylhydrazone linked 1,2,3‑triazole hybrids: synthesis, antimicrobial evaluation and docking studies as dual inhibitors of DNA gyrase and lanosterol 14‑α demethylase Res. Chem. Intermed. 2022, 48, 5089-5111 (SCI; I.F.: 3.134)
Nehra, N.; Ghule, V. D.; Tittal, R. K.* Simpler fluorescent probe for Homocysteine selective detection J. Mol. Struct 2022,1250, 131755. (SCI; I.F.: 3.841)
Nehra, N.; Tittal, R. K.*; Ghule, V. D. 1,2,3-Triazoles of 8-Hydroxyquinoline and HBT: Synthesis and Studies (DNA Binding, Antimicrobial, Molecular docking, ADME and DFT) ACS Omega 2021, 6, 27089-27100. (SCI; I.F.: 4.132)
Sandhu, N.; Pandey, S. K.; Tittal, R. K.; Kumar, K.; Singh, A. P.; Yadav, R. K.; Shrivastava, R.; Singh, A. P., Fluorescein dye derivative: Synthesis, characterization, quantum chemical and promising antimicrobial activity studies J. Heterocycl. Chem. 2021, 58, 2381-2389. (SCI; I.F.: 2.193)
Nehra, N.; Tittal, R. K.*; Ghule, V. D.; Naveen.; Lal, K., Synthesis, antifungal studies, molecular docking, ADME and DNA interaction studies of 4-hydroxyphenyl benzothiazole linked 1,2,3-triazoles J. Mol. Struct 2021, 1245, 131013. (SCI; I.F.: 3.841)
Nehra, N.; Tittal, R. K.;* Ghule, V. D.; Kumar, N.; Paul, A. K.; Lal, K.; Kumar, A. “CuAAC Mediated Synthesis of 2-HBT Linked Bioactive 1,2,3-Triazole Hybrids: Investigations through Fluorescence, DNA Binding, Molecular Docking, ADME Predictions and DFT Study” ChemistrySelect 2021, 6, 685-694. (SCI; I.F.: 2.307)
Naveen; Tittal, R. K.;* Ghule, V. D.; Rani, P.; Kumar, L.; Lal, K.; Kumar, A. “Synthesis, Antimicrobial Potency with In Silico Study of Boc-Leucine-1,2,3-Triazoles” Steriods 2020, 161, 108675. (SCI; I.F.: 2.76)
Naveen; Tittal, R. K.;* Ghule, V. D.; Rani, P.; Kumar, L.; Lal, K.; Kumar, A. “Synthesis, Antimicrobial Activity, Molecular Docking and DFT Study: Aryl-Carbamic Acid 1-Benzyl-1H-[1,2,3]Triazol-4-ylmethyl Esters” ChemistrySelect 2020, 5, 6723-6729. (SCI; I.F.: 2.307)
Mathpati, R. S.; Dharavath, S.; Kumar, N.; Ghule, V. D.; Paul, A. K.; Tittal, R. K. “Design, synthesis and investigations of a series of energetic salts through the variation of amines and concentration of picrate-anion” CrystEngComm, 2020, 22, 4842-4852. (SCI; I.F.: 3.38)
Naveen; Tittal, R. K.;* Ghule, V. D.; Kumar, N.; Kumar, L.; Lal, K.; Kumar, A. “Design, synthesis, biological activity, molecular docking and computational studies on novel 1,4-disubstituted-1,2,3-triazole-thiosemicarbazone hybrid molecules” J. Mol. Struct. 2020, 1209, 127951. (SCI; I.F.: 3.841)
Deswal, S.; Naveen; Tittal, R. K.* Ghule, V. D.; Lal, K.; Kumar, A. “5-Fluoro-1H-indole-2,3-dione-triazoles- synthesis, biological activity, molecular docking, and DFT study” J. Mol. Struct. 2020, 1209, 127982. (SCI; I.F.: 3.841)
Nehra, N.; Kaushik, R.; Ghule, V. D.; Tittal, R. K.* “Simpler molecular structure as selective & senstive ESIPT-based fluorescent probe for Cys and Hcy detection with DFT studies” J. Mol. Struct. 2020, 1207, 127839. (SCI; I.F.: 3.841)
Naveen; Tittal, R. K.;* Yadav, P.; Lal, K.; Ghule, V. D.; Kumar, A. “Synthesis molecular docking and DFT studies on biologically active 1,4-disubstituted-1,2, -3-triazole -semicarbazone hybrid molecules” New J. Chem. 2019 , 43, 8052-8058. (SCI; I.F.: 3.925)
Tittal, R. K.;* Ram, R. N.; Nirwan, A.; Ghule, V. D.; Kumar, S. “CuCl/bpy-promoted unusual Z-stereoselective synthesis of trichloroacetic acid phenyl ester for Hirshfeld surface analysis and DFT study” J. Mol. Struct. 2019, 1185, 300-309. (SCI; I.F.: 3.841)
Deswal, S.; Tittal, R. K.;* Yadav, P.; Lal, K.; Ghule, V. D.; Kumar, N. “Cellulose supported CuI-NPs-mediated green synthesis of trifluoromethylbenzoate-linked triazoles for pharmaceutical & DFT study” ChemistrySelect 2019, 4, 759-764. (SCI; I.F.: 2.307)
Tittal, R. K.* “Synthesis and molecular crystal of 3-chloro-2- (1-chloro-1-methylethyl) -2,3-dihydro-1H-naphtho (2,1b) oxepin-4-one” J. Mol. Struct. 2018, 1156, 621-626. (SCI; I.F.: 3.841)
Ram, R. N; Tittal, R. K.* “A novel β-(oxy) alkyl radical during copper(I)-mediated stereo selective synthesis of (Z)-ene-1,4-diones in a reaction of 2,2,2-trichloro-1-phenylethanone” Tetrahedron Lett. 2016, 57, 2437-2440. (SCI; I.F.: 2.42)
D. Ghule, Sonal Deswal, Alka Devi, R. K. Tittal, “Computer-Aided Design of Energetic Tris(tetrazolyl)amine derivatives and salts” Ind. Eng. Chem Res. 2016, 55, 875-881. (SCI; I.F.: 4.326)
Tittal, R. K.* ” Ring opening of epoxides by silica sulfuric acid for the synthesis of 2-Allyloxy-2-phenylethanol under solvent free condition” International Journal of Engineering Technology Science and Research 2015, 51-54. (Conference proceeding)
Sonal Deswal, V. D. Ghule, R. K. Tittal, S. Radhakrishnan” Quantum-chemical design of tetrazolo [1,5-b] [1,2,4,5] tetrazine based nitrogen-rich energetic materials” Computational and Theoretical Chemistry 2015, 1054, 55-62. (SCI; I.F.: 1.93)
Tittal, R. K.*, Kumar, S.; Ram, R. N., ” Z-2,3-dichloro-1,4-bis (4-methoxyphhenyl) but-2-ene-1,4-dione. , ” Acta Cryst 2014 , E70, o1049-o1050. (SCI; I.F.: 0.57)
Tittal, R. K.*, Kumar, S .; Ram, R. N. “Z-2.33-dichloro-1,4-bis (4-chlorophenyl) but-2-ene-1,4-dione” Acta Cryst 2014, E70, O861-O862. (SCI; I.F.: 0.57)
Ram, R. N.; Tittal, R. K.* “An evidence of contact ion pair in β-(acyloxy)alkyl radical heterolysis during copper(I)-mediated synthesis of trisubstituted alkenes” Tetrahedron Lett. 2014, 55, 4448-4451. (SCI; I.F.: 2.42)
Ram, R. N.; Tittal, R. K.* “β-(Carbonatoxy)alkyl radicals: A new subset of β-(ester)alkyl radical fragmentation during copper(I)-mediated synthesis of 1,1-dichloro-1-alkenes” Tetrahedron Lett. 2014, 55, 4342-4345. (SCI; I.F.: 2.42)
Papers presented in Conferences:
International: 10
National: 01
Invited talks: 10
Conducted a one-week Workshop as Coordinator on “Molecules & Materials Technology: Interface with R & D and Industry” (MMT-2017); during 21.03.2017-26.03.2017.
Conducted one day National Conference as Organizing Secretary on Topic Molecules & Material Technology (MMT-2018) on 21.02.18
Conducted two days National Conference as Secretary on the Topic “Promotion of Research, Mentoring & Dissemination of the IKS Knowledge through Higher Education Institutions under UBA” from 19.10.2022 to 20.10.2022
Conducted two days International Conference (Hybrid mode) as Conference Secretary on Topic “Molecules & Material Technology (MMT-2023)” from 21.04.2023 to 22.04.2023
Presented paper entitled- “Mechanism involving heterolysis of C-O bond via intermediate formation of CIP in the decarboxylative benzannulation and biaryl formation presentation” in an international conference on Recent Advances in Chemical Sciences (ICRACS-2013), Department of Chemistry, Arya PG College, Panipat, Haryana, India from 24.02.2013 to 26.02.2013.
Presented paper entitled- “O-Claisen rearrangement for the preparation of O-allyl phenols from allyloxyarenes.” in an international conference on Chemistry: Frontiers & Challenges, Department of Chemistry, AMU Aligarh, India from 02.03.2013 to 03.03.2013.
Presented poster entitled “Involvement of contact ion pair formation for the heterolysis of CO bond during copper(I) -promoted ATRC in unusual benzannulation reactions” in 20th ISCB International Conference (ISCBC -2014) on chemistry and medicinal plants in translational medicine for healthcare at Department of Chemistry, University of Delhi from 01.03.2014 to 04.03.2014.
Presented paper entitled- “Synthesis of synthetic and Biological Active Allylaryl Trichloroacetates” in XIV Annual Conference on International Academy of Physical Science on Physical Sciences and Technology for Sustainable Development at PDPM IIIT Design & Manufacturing Jabalpur, India from 20.03.2014 to 22.03.2014.
Presented poster entitled- “Mechanistic study of β-substituted alkyl radical under CuCl/bpy promoted reaction of 2,2,2-trichloroethyl 1-allyloxy phenyl 1-ester for rearrangement and 2,2,2-trichloroethyl 1-allyloxy phenyl 1-carbonate for fragmentation” in 51st annual convention of chemists-2014 organized by indian chemical society at Department of Chemistry, Kurukshetra University, Kurukshetra Haryana, India from 09.12.2014 to 12.12.2014.
Presented paper entitled- “Ring opening of epoxides by silica sulfuric acid for the synthesis of 2-allyloxy-2-phenylethanol under solvent free condition” in an international conference on emerging trends of engineering, science management and its applications (ICETESMA-2015) held at JNU Convention Center, New Delhi on 01.03.2015.
Delivered a Invited lecture as a speaker on the topic- “Clean and efficient synthesis of 1,1,1-trichloro-2-alkoxy-2-acyloxyethanes, substrates for the study of mechanism of Surzur-Tanner rearrangement” in an international conference on nascent developments in chemical sciences: Opportunities for academia-industry collaboration held at Department of Chemistry, Birla Institute of Technology & Science, Pilani, Pilani Campus from 16.10.2015 to 18.10.2015.
Delivered invited lecture on the topic- “Transition metal mediated synthesis from trichloromethyl compounds: Radical reactions” on 10.06.2016 in one-week short term course on Emerging Materials: Synthesis and Characterization held at Department of Physics, National Institute of Technology, Kurukshetra Haryana. India from 06.06.2016 to 11.06.2016.
Presented paper entitled- “Synthesis of chlorine containing seven-member benzo lactones” in an international conference on green chemistry in environmental sustainability & chemical education held at Department of Chemistry, Daulat Ram College, University of Delhi, India from 17.11.2016 to 18.11.2016.
Delivered invited lecture on the topic- “Fate of negative research results” on 28.08.2019 in an international conference on World Congress on Biotechnology-2019 Current research & Innovations in Biotechnology held at J. N. Tata auditorium IISc Bengaluru, India from 28.08.2019 to 29.08.2019.
Delivered invited lecture on the topic- “Fate of negative research results” on 27.02.2020 in an international conference on innovations and opportunities in Chemical Engineering for sustainable environment and energy held at RBS Engineering technical campus Bichpuri, Agra (India) from 27.02.2020 to 29.02.2020.
Delivered invited lecture on the topic- “Fate of negative research results” on 18.02.2021 in a Two Week Online Refresher Course (Inter/Multi-Disciplinary)- Winter School (Engineering Science) held at UGC Human Resource Development Centre of Guru Nanak Dev University, Amritsar (India) from February 10 to February 23, 2021.
Delivered invited lecture on the topic- “Research for Sustainable Progress” on 18.12.2021 in a AICTE-ISTE sponsored Faculty Development Program held at Department of Chemical Engineering, L D College of Engineering, Ahmedabad. from 16.12.2021 to 22.12.2021.
Delivered invited lecture on the topic- “Sustainable Methods for Research Process” on 05.02.2022 in a Two Week Online Refresher Course – Winter School (Engineering Science) held at UGC Human Resource Development Centre of Guru Nanak Dev University, Amritsar from 28.012022 to 11.02.2022.
Delivered invited lecture on the topic- “Effects of Stress – Digestive Health” on 09.06.2022 in a Faculty Development Program on LIFE STYLE MODIFICATIONS FOR STRESS FREE LIFE organized by Heartfulness Education Trust at MM College of Pharmacy-Mullana (Ambala) from 06.062022 to 10.06.2022.
Delivered invited lecture on the topic- “Effects of Stress – Digestive Health” on 14.06.2023 in a Faculty Development Program on LIFE STYLE MODIFICATIONS FOR STRESS FREE LIFE organized by the Department of Pharmacy, Global Research Group of Institutions, Radaur (Yamunanagar) in the association of Heartfulness Education Trust and Haryana Yoga Ayog from 12.06.2023 to 14.06.2023.
Delivered invited lecture on the topic- “Fate of negative research results” on 12.08.2023 in an International e-Conference on Recent Advances & Innovations in Applied Sciences -2023 (RAIAS-2023) organized by IITyam Indian Academy Delhi in collaboration with the Department of Chemistry, HNB Govt. PG College Khatima UK, and Department of Zoology, Govt. PG College Bazpur, UK, Department of Higher Education, Govt. of Uttarakhand, India.
Seminars / conferences / workshops / short term courses Attended: (Total: 06)
Participated in UGC sponsored Orientation Programme at UGC academic staff college, Aligarh Muslim University, Aligarh (India) from 31.01.2012 to 29.02.2012 and obtained ‘A’ grade.
Participated in UGC sponsored Refresher Course at UGC academic staff college, University of Calicut, Kerala (India) from 28.09.2012 to 18.10.2012 and obtained ‘A’ grade.
Attended ISTE-WPLP national workshop on “Effective teaching and learning pedagogy” organized by ISTE at Hotel Le Meridian, Jan path, New Delhi, India from 19-21.02. 2014.
Attended RSC roadshow workshop on “Supramolecular molecular chemistry and organic materials symposium” organized by Royal Society of Chemistry (RSC) at IIT-Delhi, India on 04.11.2014.
Awards/Honors –
Ph. D. Supervision – 08 (04 awarded, and 04 in progress)
Ph. D. Candidates:
1. Dr. Sonal Deswal (2K13-NITK-Ph.D/6130100); Title of the Ph.D. Thesis: Computational Design of Nitrogen-rich High Energy Materials and Synthesis of Some N-containing Heterocycles for Pharmacological Studies. Status of the Ph.D.: Completed (<5 Years).
Papers published from her Ph. D. thesis work:
2. Dr. Naveen (2K16-NITK-Ph.D./6160064); Title of the Ph.D. Thesis: Synthesis and Study of N-heterocycles by Click Chemistry. Status of the Ph.D.: Completed (< 4.5 Years).
Papers published from his Ph. D. thesis work
3. Dr. Nidhi Nehra (2K17-NITK-Ph.D./6170082); Title of the Ph.D. Thesis: Synthesis of Hydroxyphenyl Benzothiazole Based Acyl Derivatives for Sensing and 1,2,3-triazole Hybrids for Biological Applications. Status of the Ph.D.: Completed (<5 Years).
Paper published from her Ph. D. thesis work:
4. Dr. Ramling Shivanandyya Mathpati (2K19-NITK-Ph.D./61900006); Title of Ph.D. Thesis: Design and Synthesis of High Energy Materials based on Nitrogen-rich Backbone with Various Explosophoric Groups. Status of the Ph.D.: Completed (<4 Years). (my role: Co-supervisor, main Supervisor: Dr. Ghule Vikas D.)
Papers published from his Ph. D. thesis work
5. Mr. Bajrang Lal (2K19-NITK-Ph.D./61900124); Title of the Ph.D. Thesis: Synthesis and Study of Biologically Active 1,2,3-Triazole Hybrid Molecules. Status of the Ph.D.: Pursuing.
Paper published from his Ph. D. thesis work:
6. Ms. Kanika Sharma (2K20-NITK-Ph.D./62000055); Title of the Ph.D. Thesis: Synthesis and Study of 7-Azaindole linked 1,2,3-Triazoles. Status of the Ph.D.: Pursuing.
Paper published from her Ph. D. thesis work:
7. Mr. Sachin Kumar (Reg. No. 192SAS04310003/Roll No. 192080431003); Registered at School of applied Sciences, OM Sterling Global University, Hisar (my role: Co-Supervisor), Title of the Ph.D. Thesis: Synthesis and Photophysical Investigations of bis-1,2,3-Triazole Hybrid Molecules. Status of the Ph.D.: Pursuing.
Paper published from his Ph. D. thesis work:
8. Ms. Pooja (2K22-NITK-Ph.D./62210013); Title of the Ph.D. Thesis: Synthesis and Pharmacophoric Study of 1,2,3-Triazoles. Status of the Ph.D.: Pursuing.
M. Tech. Dissertations – 02 (Awarded)
M. Tech. Candidates:
1. Ms. Neha Pant (Roll no -31501107); Title of the M. Tech. Thesis: Syntheses of amine-templated organo-phosphonate open framework compounds and triazole derivatives. Status: Completed.
2. Ms. Vidisha Pandey (Roll no -31601102); Title of the M. Tech. Thesis: Synthesis and computational study of bis-triazole derivatives of 5-amino isophthalic acid. Status: Completed.
Sponsored R & D Projects:
Title: Development of Insensitive High Energy Materials Containing Heterocyclic Backbone Substituted with Amino, Azido, and Nitro Explosophores. Agency: ARMREB/CDSW/DRDO. Status: Completed; Role: Co-PI
Contribution –
Course Coordinator CHT-103 (2013 -14)
Course Coordinator CHT-104 (2013 -14)
Course Coordinator CHY-103P (2014-15)
Course Coordinator CHY-517T common with CHY-713T (2014-15)
Course Coordinator CHY-517T common with CHY-713T (2015-16)
Course Coordinator CHY-504T (2016-17)
Member, Board of Studies (2013-16)
Member, Departmental Advisory Committee (2013-15)
Faculty-in-charge Ph. D. Affairs (2015-2016 & 2016-19)
Member, DRC (2016-18)
Warden, Hostel No. 6 (2014-2016)
Warden, Hostel No. 5 (2017-2019)
Faculty-in-charge PG Club under Student Club (2016-17)
Member, Institute Library Committee (2016-19)
Research Collaborations – Dr. Ghule Vikas D (National Institute of Technology, Kurukshetra); Dr. Kashmiri Lal (Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar)
Other:
Life Time Member of the Indian Science Congress Association (L20609)
Life member of the Indian Council of Chemists ( LF / 1739 )
